![]() ![]() This may apply in the case of single point calibrations, where a single concentration of standard is used for the calibration, or in multi-level calibration where the original weighing is diluted to prepare a series of standards over a range of concentrations. The idea is that if the response is corrected using the actual amount which was weighed out, then the response factors will be the same if the weighing has been performed correctly. Replicates in calibration standard preparation are often used to provide confidence in the initial weighing of the standard material. ![]() In the case of measurement replicates, a single sample/standard is measured more than once (an example would be multiple injections in the case of HPLC). In the case of preparation, these are samples or standards that are prepared from the beginning to end of the procedure in the same way but separately (often referred to as replicate weighings). Most commonly it comes down to two types, either preparation replicates or measurement replicates. There are different types of replicates in analytical methods, which are used for different purposes. Do you prepare your samples/standards in duplicate without really thinking about it? If challenged on why, would your answer be something like, "it's good practice, isn't it?" The use of replicates in analytical procedures is commonplace but it is important to understand why you are doing it and also what the results are telling you. ![]()
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